YAP1 和 WWTR1 (TAZ) 刺激基因表达
中文名称
通路描述
YAP1 和 WWTR1 (TAZ) 是转录共激活因子，两者都是果蝇 Yorkie 蛋白的同源物。它们都与 TEAD 家族转录因子的成员相互作用，WWTR1 也与 TBX5 和 RUNX2 相互作用，以促进基因表达。它们的转录靶基因包括细胞增殖和凋亡调节的关键基因。它们的亚细胞定位由 Hippo 信号通路调节：该通路介导的磷酸化导致这两种蛋白的细胞质滞留 (Murakami et al. 2005; Oh and Irvine 2010)。
英文描述
YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 interacts as well with TBX5 and RUNX2, to promote gene expression. Their transcriptional targets include genes critical to regulation of cell proliferation and apoptosis. Their subcellular location is regulated by the Hippo signaling cascade: phosphorylation mediated by this cascade leads to the cytosolic sequestration of both proteins (Murakami et al. 2005; Oh and Irvine 2010).
所含基因
15 个基因