NOSTRIN 介导的 eNOS 转运
中文名称
通路描述
NOSTRIN 介导的 eNOS 转运 eNOS 转运诱导物 (NOSTRIN) 是一种新型 506 个氨基酸长的 eNOS 相互作用蛋白。与 eNOS 活性降低相比，NOSTRIN 导致 eNOS 从质膜向细胞内囊泡结构转位。NOSTRIN 通过同源三聚化和招募 eNOS、dynamin-2 和 N-WASP 到其 SH3 域发挥作用。研究表明，NOSTRIN 可能通过协调 dynamin 和 N-WASP 的功能促进 eNOS 的囊泡分裂和内吞，进而招募 Arp2/3 复合物，启动肌动蛋白丝聚合。总体而言，该过程被认为通过腔泡内吞发生。
英文描述
NOSTRIN mediated eNOS trafficking eNOS traffic inducer (NOSTRIN) is a novel 506-amino acid eNOS-interacting protein. Along with a decrease in eNOS activity, NOSTRIN causes translocation of eNOS from the plasma membrane to intracellular vesicular structures. NOSTRIN functions as an adaptor protein through homotrimerization and recruitment of eNOS, dynamin-2, and N-WASP to its SH3 domain. Studies indicated that NOSTRIN may facilitate vesicle fission and endocytosis of eNOS by coordinating the function of dynamin and N-WASP, which in turn, recruits the Arp2/3 complex, initiating actin filament polymerization. Overall, this process is thought to occur via caveolar endocytosis.
所含基因
5 个基因