亚麻酸代谢
中文名称
通路描述
亚麻酸 (LA, 18:2(n-6)) 是一种通过饮食获得的omega-6脂肪酸，主要来源于植物油。omega-6脂肪酸有助于刺激皮肤和头发生长，维持骨骼健康，调节代谢，并维持生殖系统。所有脱饱和和延长步骤均发生在内质网 (ER) 中，除了最后一步需要转位至过氧化物酶体进行部分beta-氧化。亚麻酸途径涉及以下步骤：18:2(n-6)-->18:3(n-6)--> 20:3(n-6)-->20:4(n-6)-->22:4(n-6)-->24:4(n-6)-->24:5(n-6)-->22:5(n-6)。该过程中涉及两种脱饱和酶：delta-6脱饱和酶将18:2(n-6)转化为18:3 (n-6)，以及将24:4(n-6)转化为24:5(n-6)；delta-5脱饱和酶将20:3(n-6)转化为20:4(n-6)。
英文描述
Linoleic acid (LA) metabolism Linoleic acid (LA, 18:2(n-6)) is an omega-6 fatty acid obtained through diet, mainly from vegetable oils. Omega-6 fatty acids helps stimulate skin and hair growth, maintain bone health, regulate metabolism, and maintain the reproductive system. All the desaturation and elongation steps occur in the endoplasmic reticulum (ER) except for the final step which requires translocation to peroxisomes for partial beta-oxidation. The linoleic acid pathway involves the following steps: 18:2(n-6)-->18:3(n-6)--> 20:3(n-6)-->20:4(n-6)-->22:4(n-6)-->24:4(n-6)-->24:5(n-6)-->22:5(n-6). Two desaturation enzymes are involved in this process: delta-6 desaturase which converts 18:2(n-6) to 18:3 (n-6) and 24:4(n-6) to 24:5(n-6) respectively, and delta-5 desaturase which converts 20:3(n-6) to 20:4(n-6). (Sprecher 2002).
所含基因
8 个基因