NFG和proNGF与p75NTR结合
中文名称
通路描述
当共受体sortilin存在于细胞表面时，proNGF优先与p75NTR:sortilin复合物相互作用。因此，proNGF不结合TRKA，在同时表达两种受体的细胞中，区分TRKA和p75NTR。同样，proBDNF也遵循此机制。pro-neurotrophin与p75NTR:sortilin结合可激活凋亡级联，这可能涉及受伤后的细胞死亡，以及阿尔茨海默病等神经退行性疾病。
英文描述
NFG and proNGF binds to p75NTR When the co-receptor sortilin is present at the cell surface, proNGF preferentially interacts with a p75NTR:sortilin complex. Thus, proNGF, which does not bind TRKA, discriminates between TRKA and p75NTR, in cells that express both receptors. The same is true for proBDNF. Pro-neurotrophin binding to p75NTR:sortilin activates an apoptotic cascade, which may be involved in cell death after injury, and in neurodegenerative diseases such as Alzheimer's dementia.
所含基因
3 个基因