NRIF 信号诱导细胞死亡
中文名称
通路描述
NRIF（核受体相互作用因子）是一种 DNA 结合蛋白，对于视网膜和交感神经中的 p75 介导的凋亡至关重要。神经生长因子或前神经生长因子与 p75TR 结合，诱导 NRIF 发生核转位，该过程涉及 p75NTR 胞内区（ICD）的γ分泌酶切割。一旦进入细胞核，NRIF 介导凋亡，可能通过作为转录因子的作用来实现。
英文描述
NRIF signals cell death from the nucleus NRIF (nuclear receptor-interacting factor) is a DNA binding protein that is essential for p75-mediated apoptosis in retina and sympathetic neurons. Neurotrophin or proneurotrophin binding to p75TR induces nuclear translocation of NRIF, which involves gamma-secretase cleavage of p75NTR ICD (Intra Cellular Domain). Once in the nucleus, NRIF mediates apoptosis, probably by acting as transcription factor.
所含基因
16 个基因