星形胶质细胞的谷氨酸 - 谷氨酰胺摄取和代谢
中文名称
通路描述
在星形胶质细胞的谷氨酸 - 谷氨酰胺循环中，突触间隙由前突触神经元释放的过量谷氨酸通过一种称为兴奋性氨基酸转运体 1 和 2（EAAT1 和 EAAT2）的谷氨酸转运系统被转运到星形胶质细胞。携带这些转运体的星形胶质细胞与突触紧密相邻，以清除过量谷氨酸以防止神经元过度激活从而避免神经元死亡。星形胶质细胞中的谷氨酸被谷氨酰胺合成酶转化为谷氨酰胺。谷氨酰胺随后通过系统 N 转运体转运到细胞外空间。细胞外空间的谷氨酸可供神经元摄取。
英文描述
Astrocytic Glutamate-Glutamine Uptake And Metabolism In astrocytic glutamate-glutamine cycle, the excess glutamate released by the pre-synaptic neuron in the synaptic cleft is transported into the astrocyte by a family glutamate transporters called the excitatory amino acid transporters 1 and 2, EAAT1 and EAAT2. Astrocytes carrying these transporters exist in close apposition to the synapse to clear excess glutamate to prevent excessive activation of neurons and hence neuronal death. Glutamate in astrocytes is converted to glutamine by glutamine synthetase. Glutamine is then transported into the extracellular space by system N transporters. The glutamate in the extracellular space is available for neuronal uptake.
所含基因
4 个基因