晚期（分支形态发生）胰腺芽原基前体细胞中基因表达的调控
中文名称
通路描述
晚期（分支形态发生）胰腺芽原基前体细胞中转录网络的性质是从小鼠模型中已研究透彻的网络中推断的。在小鼠中，已分化的但尚未分化的上皮细胞被组织成分支导管结构。在分子水平上，Pdx1、Nkx2.2 和 Nkx6.1 的表达降低，而 Hnf6 的表达保持高水平。Hnf6 介导 Onecut3 和 Hnf1 beta 的持续表达以及上皮细胞增殖。随着 Ngn3（对应人类 NEUROG3）的表达上升，上皮细胞的内分泌分化开始（Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003）。
英文描述
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells The properties of transcriptional networks in late stage (branching morphogenesis) pancreatic bud precursor cells are inferred from the properties of well-studied networks in mouse models. In mice, committed but undifferentiated epithelial cells are organized into branching ductal structures. At a molecular level, expression of Pdx1, Nkx2.2, and Nkx6.1 is reduced while Hnf6 expression remains high. Hnf6 mediates the continued expression of Onecut3 and Hnf1 beta and epithelial cell proliferation. As expression of Ngn3 (corresponds to human NEUROG3) rises, endocrine differentiation of the epithelial cells begins (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003).
所含基因
16 个基因