β细胞中基因表达的调控
中文名称
通路描述
PDX1 和 HNF1A 两个转录因子在维持成熟β细胞在胰腺内分泌中特有的基因表达模式中起着关键作用。这些调节分子的靶基因包括编码胰岛素、GLUT2 葡萄糖转运蛋白、肝（和胰腺）特异性丙酮酸激酶以及其他转录因子，包括 HNF4A、HNF4G 和 FOXA3。PDX1 的表达反过来受 MAFA、FOXA2 和 PAX6 活性的控制，并通过 AKT 负向调节（Chakrabarti and Mirmira 2003; Servitja and Ferrer 2004）。
英文描述
Regulation of gene expression in beta cells Two transcription factors, PDX1 and HNF1A, play key roles in maintaining the gene expression pattern characteristic of mature beta cells in the endocrine pancreas. Targets of these regulatory molecules include genes encoding insulin, the GLUT2 glucose transporter, the liver- (and pancreas) specific form of pyruvate kinase and other transcription factors including HNF4A, HNF4G, and FOXA3. PDX1 expression in turn is controlled by the activities of MAFA, FOXA2, and PAX6, and negatively regulated via AKT (Chakrabarti and Mirmira 2003; Servitja and Ferrer 2004).
所含基因
15 个基因