内分泌已分化（NEUROG3+）前体细胞中基因表达的调控
中文名称
通路描述
小鼠模型研究表明，神经发生素 3 在胰腺发育中诱导内分泌分化中起着中心作用（Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003）。在人和小鼠中，这一诱导过程中的关键事件包括神经发生素 3（NEUROG3）依赖性转录 PAX4、NEUROD1、NKX2-2 和 INSM1。
英文描述
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Studies in mouse model systems indicate that the transcription factor neurogenin 3 plays a central role in the induction of endocrine differentiation in the developing pancreas (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003). In both mice and humans critical events in this induction process include the neurogenin 3 (NEUROG3)-dependent transcription of PAX4, NEUROD1, NKX2-2, and INSM1.
所含基因
4 个基因