早期胰腺前体细胞中基因表达的调控
中文名称
通路描述
人类胰腺细胞分化早期转录网络的性质是从小鼠模型中已研究透彻的网络中推断的。在小鼠中，胰腺发育的第一个可见迹象是胚胎第 9 天左右出现胰腺芽。这些芽中的细胞已经分化为外分泌和内分泌胰腺的专门细胞。Hnf1b、Hnf6 和 Pdx1 等转录因子的表达，以及对 Fgf10（成纤维细胞生长因子 10）的反应性，上调了 Ptf1、Onecut3、LRh1 和 Nkx6.1 因子的表达（Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003）。
英文描述
Regulation of gene expression in early pancreatic precursor cells The properties of transcriptional networks early in the differentiation of human pancreatic cells are inferred from the properties of well-studied networks in mouse models. In mice, the first visible sign of pancreatic development is the appearance of pancreatic buds at about embryonic day 9. The cells in these buds are already committed to differentiate into specialized cells of the exocrine and endocrine pancreas. Expression of transcription factors including Hnf1b, Hnf6, and Pdx1, as well as responsiveness to Fgf10 (fibroblast growth factor 10), up-regulates the expression of factors including Ptf1, Onecut3, Lrh1, and Nkx6.1 (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003).
所含基因
6 个基因