Basigin 相互作用
中文名称
通路描述
Basigin 是一种广泛表达的跨膜糖蛋白，属于 Ig 超家族，高度富集于上皮细胞表面。Basigin 参与各种免疫现象、分化和发展中的细胞间相互作用，但其主要功能是刺激多种基质金属蛋白酶的合成。Basigin 还通过刺激 VEGF 产生诱导血管生成。Basigin 具有两个 Ig 样结构域的胞外区，N 端 Ig 样结构域参与相互作用。它通过基底细胞或相邻细胞上的 Basigin 分子之间的相互作用进行相互作用。它还与其他多种蛋白质相互作用，如钙粘蛋白 -1、环肽素、整合素和 Annexin II，这些蛋白质在细胞增殖、能量代谢、迁移、粘附和运动，特别是在癌症转移中起重要作用。
英文描述
Basigin interactions Basigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interactions involved in various immunologic phenomena, differentiation, and development, but a major function of basigin is stimulation of synthesis of several matrix metalloproteinases. Basigin also induces angiogenesis via stimulation of VEGF production.
Basigin has an extracellular region with two Ig-like domains of which the N-term Ig-like domain is involved in interactions. It undergoes interactions between basigin molecules on opposing cells or on neighbouring cells. It also interacts with a variety of other proteins like caveolin-1, cyclophilins, integrins and annexin II that play important roles in cell proliferation, energy metabolism, migration, adhesion and motion, especially in cancer metastasis.
Basigin has an extracellular region with two Ig-like domains of which the N-term Ig-like domain is involved in interactions. It undergoes interactions between basigin molecules on opposing cells or on neighbouring cells. It also interacts with a variety of other proteins like caveolin-1, cyclophilins, integrins and annexin II that play important roles in cell proliferation, energy metabolism, migration, adhesion and motion, especially in cancer metastasis.
所含基因
25 个基因