Tie2 信号传导
中文名称
通路描述
Tie2/Tek 受体酪氨酸激酶在血管和造血发育中起关键作用，且仅表达于内皮细胞系。Tie2 与一组属于血管生成素家族的配体相互作用并发生激活。这些配体具有相反的作用：血管生成素 1 和血管生成素 4 刺激 Tie2 磷酸化，而血管生成素 2 抑制其磷酸化。在酪氨酸磷酸化后，Tie2 作为各种信号蛋白的支架，参与不同的信号转导级联反应，这些信号可影响内皮细胞生存和血管生成芽的形成。
英文描述
Tie2 Signaling The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belonging to angiopoietin family and undergoes activation.
These ligands show opposing actions, angiopoietin 1 and angiopoietin 4 stimulate the Tie2 phosphorylation and angiopoietin 2 inhibits it. Upon tyrosine phosphorylation Tie2 acts as a scaffold for various signaling proteins involved in different signal transduction cascades that can effect survival of endothelium and angiogenic sprout formation.
These ligands show opposing actions, angiopoietin 1 and angiopoietin 4 stimulate the Tie2 phosphorylation and angiopoietin 2 inhibits it. Upon tyrosine phosphorylation Tie2 acts as a scaffold for various signaling proteins involved in different signal transduction cascades that can effect survival of endothelium and angiogenic sprout formation.
所含基因
14 个基因