ERBB2信号下调
中文名称
通路描述
ERBB2信号可通过泛素化及随后的泛素依赖性降解下调，或激活的ERBB2异二聚体。此外，ERBB2 C-末端的酪氨酸磷酸酶（如PTPN12和PTPN18）去磷酸化酪氨酸残基，从而阻止信号转导至RAS和PI3K效应分子。
英文描述
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. It is most active in catalyzing N-hydroxylation or N-dealkylation reactions.
所含基因
1 个基因