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Sterols are 12-hydroxylated by CYP8B1

Reactome ID: R-HSA-211994

中文名称

过氧化物体自噬

通路描述

过氧化物体是细胞质中的细胞器,负责分解支链和长链脂肪酸以及减少活性氧(ROS)。过氧化物体的稳态对于维持ROS水平至关重要。因此,消除功能失调的过氧化物体很重要。过氧化物体通过自噬降解被称为过氧化物体自噬(Katarzyna ZR 等,2016)。过氧化物体自噬可由营养条件的变化触发。
英文描述
Sterols are 12-hydroxylated by CYP8B1 Cytochrome P450 8B1 (CYP8B1, sterol 12-alpha- hydroxylase) has a broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. It is also involved in bile acid synthesis and is responsible for the balance between the formation of cholic acid and chenodeoxycholic acid (Gafvels et al. 1999).

所含基因

1 个基因