GLI2 蛋白被蛋白酶体降解
中文名称
通路描述
GLI2 蛋白的主要作用是在 Hh 信号通路受刺激时作为激活因子；在没有 Hh 配体时，一小部分 GLI2 被加工为抑制因子形式，但大部分蛋白被蛋白酶体完全降解（综述自 Briscoe and Therond, 2013）。GLI2 的加工和降解依赖于 PKA、CK1 和 GSK3 对多个丝氨酸残基的级联磷酸化，这与 GLI3 加工所需的这些激酶需求相似（Pan et al, 2009; Pan et al, 2006; Pan and Wang, 2007）。GLI2 和 GLI3 的差异性加工取决于 C 端蛋白中的加工决定域（PDD），该域在缺乏 Hh 信号时指导 GLI3 的部分蛋白水解。将 GLI3 的 2 个氨基酸替换到 GLI2 蛋白中足以促进 GLI2 高效加工为抑制因子形式（Pan and Wang, 2007）。
英文描述
Molecules associated with elastic fibres Proteins found associated with microfibrils include vitronectin (Dahlback et al. 1990), latent transforming growth factor beta-binding proteins (Kielty et al. 2002, Munger & Sheppard 2011), emilin (Bressan et al. 1993, Mongiat et al. 2000), members of the microfibrillar-associated proteins (MFAPs, Gibson et al.1996), and fibulins (Roark et al. 1995, Yanagisawa et al. 2002). The significance of these interactions is not well understood but may help mediate elastin-fibrillin interactions during elastic fibre assembly.
Proteoglycans such as versican (Isogai et al. 2002), biglycan, and decorin (Reinboth et al. 2002) can interact with the microfibrils. They confer specific properties including hydration, impact absorption, molecular sieving, regulation of cellular activities, mediation of growth factor association, and release and transport within the extracellular matrix (Buczek-Thomas et al. 2002). In addition, glycosaminoglycans have been shown to interact with tropoelastin through its lysine side chains (Wu et al. 1999) regulating tropoelastin assembly (Tu and Weiss, 2008).
Proteoglycans such as versican (Isogai et al. 2002), biglycan, and decorin (Reinboth et al. 2002) can interact with the microfibrils. They confer specific properties including hydration, impact absorption, molecular sieving, regulation of cellular activities, mediation of growth factor association, and release and transport within the extracellular matrix (Buczek-Thomas et al. 2002). In addition, glycosaminoglycans have been shown to interact with tropoelastin through its lysine side chains (Wu et al. 1999) regulating tropoelastin assembly (Tu and Weiss, 2008).
所含基因
37 个基因