DAP12 相互作用
中文名称
通路描述
DAP12 是 12kDa 的 DNA 激活蛋白，是一种含有免疫受体酪氨酸基激活基序（ITAM）的适配器分子，在自然杀伤（NK）细胞和髓系细胞中传递激活信号。它介导这些细胞表达的多种细胞表面受体的信号转导，通过与受体链结合，形成盐桥，该结合发生在疏水脂质双分子层中（Lanier 等，1998）。DAP12 同源二聚体与多种由巨噬细胞、单核细胞和髓系细胞表达的受体结合，包括 TREM2、Siglec H 和 SIRP-β，以及由 NK 细胞表达的激活 KIR、LY49 和 NKG2C 蛋白。DAP12 在细胞表面表达，大部分蛋白质位于膜的内侧（Turnbull & Colonna 2007, Tessarz & Cerwenka 2008）。
英文描述
DAP12 interactions DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cells. It mediates signalling for multiple cell-surface receptors expressed by these cells, associating with receptor chains through complementary charged transmembrane amino acids that form a salt-bridge in the context of the hydrophobic lipid bilayer (Lanier et al. 1998). DAP12 homodimers associate with a variety of receptors expressed by macrophages, monocytes and myeloid cells including TREM2, Siglec H and SIRP-beta, as well as activating KIR, LY49 and the NKG2C proteins expressed by NK cells. DAP12 is expressed at the cell surface, with most of the protein lying on the cytoplasmic side of the membrane (Turnbull & Colonna 2007, Tessarz & Cerwenka 2008).
所含基因
20 个基因