NGF 刺激转录
中文名称
通路描述
NGF 刺激诱导广泛的转录靶标表达。在 rat PC12 细胞中，NGF 信号通路的常用模型，NGF 刺激导致细胞退出细胞周期并经历分化程序，进而引发轴突生长。该程序由立即早期基因（IEGs）的表达驱动，这些基因通常编码调节 NGF 特异性延迟响应基因活性的转录因子（综述见 Sheng and Greenberg, 1990; Flavell and Grennberg, 2008; Santiago and Bashaw, 2014）。
英文描述
EGFR Transactivation by Gastrin Gastrin, through the action of diacylglycerol produced from downstream G alpha (q) events, transactivates EGFR via a PKC-mediated pathway by activation of MMP3 (Matrix Metalloproteinase 3) which allows formation of mature HBEGF (heparin-binding epidermal growth factor) by cleaving pro-HBEGF. Mature HBEGF is then free to bind the EGFR, resulting in EGFR activation (Dufresne et al. 2006, Liebmann 2011).
所含基因
5 个基因