磷脂酶 C介导的级联反应;FGFR2
中文名称
通路描述
磷脂酶 C-γ(PLC-γ)是成纤维细胞生长因子受体(FGFR)和其他具有酪氨酸激酶活性的受体的底物。已知PLC-γ的Src同源结构域2(SH2结构域)和其他信号分子(如GTP酶激活蛋白和磷脂酰肌醇3-激酶-associated p85)的SH2结构域将其结合指向FGFR的自磷酸化酪氨酸残基。PLC-γ的招募导致其受体介导的磷酸化和激活。激活的PLC-γ水解磷脂酰肌醇[4,5]P2形成第二信使二酰甘油(DAG)和Ins[1,4,5]P3，刺激钙释放和钙/钙调蛋白依赖性激酶的激活。
英文描述
Condensation of Prophase Chromosomes In mitotic prophase, the action of the condensin II complex enables initial chromosome condensation.
The condensin II complex subunit NCAPD3 binds monomethylated histone H4 (H4K20me1), thereby associating with chromatin (Liu et al. 2010). Binding of the condensin II complex to chromatin is partially controlled by the presence of RB1 (Longworth et al. 2008).
Two mechanisms contribute to the accumulation of H4K20me1 at mitotic entry. First, the activity of SETD8 histone methyltransferase peaks at G2/M transition (Nishioka et al. 2002, Rice et al. 2002, Wu et al. 2010). Second, the complex of CDK1 and cyclin B1 (CDK1:CCNB1) phosphorylates PHF8 histone demethylase at the start of mitosis, removing it from chromatin (Liu et al. 2010).
Condensin II complex needs to be phosphorylated by the CDK1:CCNB1 complex, and then phosphorylated by PLK1, in order to efficiently condense prophase chromosomes (Abe et al. 2011).
The condensin II complex subunit NCAPD3 binds monomethylated histone H4 (H4K20me1), thereby associating with chromatin (Liu et al. 2010). Binding of the condensin II complex to chromatin is partially controlled by the presence of RB1 (Longworth et al. 2008).
Two mechanisms contribute to the accumulation of H4K20me1 at mitotic entry. First, the activity of SETD8 histone methyltransferase peaks at G2/M transition (Nishioka et al. 2002, Rice et al. 2002, Wu et al. 2010). Second, the complex of CDK1 and cyclin B1 (CDK1:CCNB1) phosphorylates PHF8 histone demethylase at the start of mitosis, removing it from chromatin (Liu et al. 2010).
Condensin II complex needs to be phosphorylated by the CDK1:CCNB1 complex, and then phosphorylated by PLK1, in order to efficiently condense prophase chromosomes (Abe et al. 2011).
所含基因
37 个基因