SREBF (SREBP) 激活基因表达
中文名称
通路描述
SREBPs (SREBP1A/1C/2, SREBFs) 在转运到细胞核后，结合靶基因启动子中的短序列，即固醇调节元件 (SREs)。(参见 Eberle et al. 2004, Weber et al. 2004)。SREBPs 本身作为转录激活相对较弱，其中 SREBP1C 比 SREBP1A 或 SREBP2 弱得多。与其他转录因子如 SP1 和 NF-Y 结合时，SREBPs 成为更强的激活剂。SREBP1C 似乎更特异性地靶向参与脂肪酸合成的基因，而 SREBP2 似乎靶向参与胆固醇合成的基因 (Pai et al. 1998)。
英文描述
Activation of gene expression by SREBF (SREBP) After transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2004). SREBPs alone are relatively weak activators of transcription, with SREBP1C being significantly weaker than SREBP1A or SREBP2. In combination with other transcription factors such as SP1 and NF-Y the SREBPs are much stronger activators. SREBP1C seems to more specifically target genes involved in fatty acid synthesis while SREBP2 seems to target genes involved in cholesterol synthesis (Pai et al. 1998).
所含基因
41 个基因