MASTL 促进有丝分裂进展
中文名称
通路描述
MASTL 活性，也称为 Greatwall 激酶（GWL），对于有丝分裂的进入和进展是必要的。有丝分裂进入期间，MASTL 的多个关键残基被磷酸化。Ser 残基 S875（Xenopus 中为 S883）的磷酸化，可能通过自磷酸化（Blake-Hodek 等人 2012）出现，似乎至关重要（Vigneron 等人 2011）。其他位点，包括潜在的 CDK1 靶点 T194、T207 和 T741，有助于 MASTL 的完全激活（Yu 等人 2006, Blake-Hodek 等人 2012）。其他激酶，如 PLK1（Vigneron 等人 2011）和其他 MASTL 磷酸化位点，也可能在功能上重要（Yu 等人 2006, Blake-Hodek 等人 2012）。
英文描述
MASTL Facilitates Mitotic Progression The activity of MASTL, also known as the Greatwall kinase (GWL), is necessary for the entry and progression of mitosis. MASTL is activated by phosphorylation of several key residues during mitotic entry. Phosphorylation on the serine residue S875 (S883 in Xenopus), likely through autophosphorylation (Blake-Hodek et al. 2012) appears to be critical (Vigneron et al. 2011). Several other sites, including putative CDK1 targets T194, T207 and T741, contribute to the full activation of MASTL (Yu et al. 2006, Blake-Hodek et al. 2012). Other kinases, such as PLK1 (Vigneron et al. 2011) and other MASTL phosphorylation sites may also be functionally important (Yu et al. 2006, Blake-Hodek et al. 2012).
Activated MASTL phosphorylates ARPP19 and ENSA on serines S62 and S67, respectively, enabling them to bind to and inhibit the phosphatase activity of PP2A complexed with the regulatory subunit PPP2R2D (B55-delta). Inhibition of PP2A-PPP2R2D activity by ARPP19 or ENSA prevents dephosphorylation of CDK1 targets, hence allowing entry and maintenance of mitosis (Mochida et al. 2010, Gharbi-Ayachi et al. 2010, Burgess et al. 2010).
Activated MASTL phosphorylates ARPP19 and ENSA on serines S62 and S67, respectively, enabling them to bind to and inhibit the phosphatase activity of PP2A complexed with the regulatory subunit PPP2R2D (B55-delta). Inhibition of PP2A-PPP2R2D activity by ARPP19 or ENSA prevents dephosphorylation of CDK1 targets, hence allowing entry and maintenance of mitosis (Mochida et al. 2010, Gharbi-Ayachi et al. 2010, Burgess et al. 2010).
所含基因
10 个基因