通过 FYN 激活的 NTRK2 信号
中文名称
通路描述
在鼠脑中，Bdnf 诱导的 Ntrk2 (TrkB) 信号导致 AMPA 受体亚基 Gria2、Gria3 和 Gria1 的蛋白水平增加，而 mRNA 水平不变。BDNF 介导的 NTRK2 激活通过 FYN 磷酸化电压门控钠通道，导致钠电流减少。FYN 下游的激活与寡星形胶质细胞的髓鞘形成有关，并参与 BDNF 诱导的 ERK1/2 (MAPK3/1) 激活，机制尚不清楚。此外，FYN 和其他 SRC 激酶，由 GPCRs 等受体激活，可能磷酸化 NTRK2 并增强其催化活性。
英文描述
Activation of the phototransduction cascade The photoreceptor cascade starts with light isomerization of 11-cis-retinal (11cRAL) of rhodopsin (RHO) to all-trans-retinal (atRAL), inducing a conformational change in RHO to the active, metarhodopsin II (MII) state. MII activates the G protein transducin (Gt) that in turn activates phosphodiesterase 6 (PDE6). Consequently, there is a fall in the intracellular concentration of cGMP that closes cGMP-dependent cation channels (CNG channels) and hyperpolarizes the rod. This has the effect of reducing or stopping glutamate release from synaptic vesicles thus signalling to the surrounding cells how many photons were absorbed (Burns & Pugh 2010, Korenbrot 2012, Pugh & Lamb 1993).
所含基因
9 个基因