调节缝隙连接活性
中文名称
通路描述
Src 被认为通过磷酸化 Cx43 来抑制缝隙连接通信。c-Src (Giepmans et al. 2001; Sorgen et al. 2004)、PKc (Lin et al. 2003) 和 MAPK (Mograbi et al. 2003) 在 Cx 的磷酸化中起关键作用，导致其降解。c-Src 似乎与 Cx43 结合并对其进行磷酸化，导致缝隙连接关闭。证据表明 v-src 可能激活 MAPK，进而磷酸化 Cx43 上的丝氨酸位点，导致通道门控 (Zhou et al. 1999)。
英文描述
Inactivation, recovery and regulation of the phototransduction cascade To terminate the single photon response and restore the system to its basal state, the three activated intermediates in phototransduction, rhodopsin (MII), transducin alpha subunit with GTP bound (GNAT1-GTP) and phosphodiesterase 6 (PDE6) all need to be efficiently deactivated. In addition, the cGMP concentrations must be restored to support reopening of the CNG channels. This section describes the inactivation and recovery events of the activated intermediates involved in phototransduction (Burns & Pugh 2010, Korenbrot 2012).
所含基因
29 个基因