积云细胞与透明带的相互作用
中文名称
通路描述
典型的哺乳动物卵细胞被约 3000 个积云细胞包裹。精子穿过积云细胞层后，与包围卵母细胞的透明带 (ZP) 相互作用。ZP 是一种糖蛋白基质，在物种特异性精卵结合、顶体反应诱导及防止多精受精中起重要作用。
英文描述
Interaction With Cumulus Cells And The Zona Pellucida A typical mammalian egg is surrounded by an outer layer of about 3,000 cumulus cells embedded in an extracellular matrix rich in hyaluronic acid. It is suggested that the fertilizing sperm with it's acrosome intact, passes through the cumulus cell layer. The zona pellucida (ZP), a glycoproteinaceous matrix surrounding the mammalian oocyte plays an important role in species specific sperm-egg binding, induction of acrosome reaction in the ZP bound spermatozoa, avoidance of polyspermy and protection of the embryo prior to implantation. The human ZP matrix is composed of 4 glycoproteins designated as ZP1, ZP2, ZP3 and ZP4.
所含基因
11 个基因