EGFR 与磷脂酶 C-gamma相互作用
中文名称
通路描述
活化的表皮生长因子受体（EGFR）可刺激磷脂酰肌醇（PI）周转。活化的 EGFR 可激活磷脂酶 C-gamma1（PLC-gamma1，即 PLCG1），该酶水解磷脂酰肌醇 4,5-二磷酸（PIP2）产生肌醇 1,4,5-三磷酸（IP3）和二酰甘油（DAG）。IP3 介导细胞内钙库中钙离子的释放，而 DAG 参与蛋白激酶 C 的激活。
英文描述
TRIF-mediated programmed cell death TLR3 and -4 trigger TRIF-dependent programmed cell death in various human and mouse cells (Kalai M et al. 2002; Han KJ et al. 2004; Kaiser WJ and Offermann MK 2005; Estornes Y et al. 2012; He S et al. 2011). Apoptosis is a prevalent form of programmed cell death and is mediated by the activation of a set of caspases. In addition to apoptosis, TLR3/TLR4 activation induces RIP3-dependent necroptosis. These two programmed cell-death pathways may suppress each other. When the caspase activity is impaired or inhibited, certain cell types switch the apoptotic death program to necroptosis in response to various stimuli (TNF, Fas, viral infection and other stress stimuli) (Kalai M et al. 2002; Weber A et al. 2010; Feoktistova M et al. 2011, Tenev et al 2011).
所含基因
8 个基因