细胞质铁硫簇组装
中文名称
通路描述
含有 4 个铁原子和 4 个硫原子的铁硫簇（4Fe-4S 簇）在细胞质上由 NUBP2 和 NUBP1 亚基组成的异四聚体支架组装而成（参见 Lill 等人 2012 年、Rouault 等人 2012 年、Sharma 等人 2010 年、Lill 和 Muhlenhoff 2006 年综述）。铁和硫的来源尚不确定，但该过程需要一种由 ABCB7（ABC7）介导从线粒体中出口含硫化合物的来源。新合成的 4Fe-4S 簇通过 CIA 靶向复合体转移到空载蛋白，如 XPD 和 POLD1，该复合体由 NARFL、CIAO1、FAM96B 和 MMS19 组成。
英文描述
Cytosolic iron-sulfur cluster assembly Iron-sulfur clusters containing 4 atoms of iron and 4 atoms of sulfur (4Fe-4S clusters) are assembled in the cytosol on a heterotetrameric scaffold composed of NUBP2 and NUBP1 subunits (reviewed in Lill et al. 2012, Rouault et al. 2012, Sharma et al. 2010, Lill and Muhlenhoff 2006). The sources of iron and sulfur are uncertain but the process requires a sulfur-containing compound exported from mitochondria via ABCB7 (ABC7). Newly synthesized 4Fe-4S are transferred to apoproteins such as XPD and POLD1 via the CIA targeting complex, composed of NARFL, CIAO1, FAM96B, and MMS19.
所含基因
13 个基因