核膜崩解
中文名称
通路描述
核膜崩解（NEBD）发生在有丝分裂的晚前期，涉及核孔复合体的解聚、核骨架的解聚以及核膜从染色质中的清除。NEBD 允许有丝分裂纺锤体微管进入凝缩的着丝粒，并实现遗传物质的核分裂和分配到两个子细胞中。对于最近的综述，请参阅 Guttinger et al. 2009。在有丝分裂前期，染色质从核膜分离，这有助于核膜崩解。VRK1（以及可能还有 VRK2）介导的 BANF1（BAF）磷酸化，一种同时与 DNA、LE 结构域内核膜蛋白和核丝相互作用的蛋白，被认为是核膜从染色质分离过程中的关键步骤之一（Bengtsson and Wilson 2006, Nichols et al. 2006, Gorjanacz et al. 2007）。
英文描述
Nuclear Envelope Breakdown The nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelope from chromatin. NEBD allows mitotic spindle microtubules to access condensed chromosomes at kinetochores and enables nuclear division and segregation of genetic material to two daughter cells. For a recent review, please refer to Guttinger et al. 2009.
In mitotic prophase, chromatin detaches from the nuclear envelope, and this contributes to the nuclear envelope breakdown. VRK1 (and possibly VRK2) mediated phosphorylation of BANF1 (BAF), a protein that simultaneously interacts with DNA, LEM-domain inner nuclear membrane proteins, and lamins (Zheng et al. 2000, Shumaker et al. 2001, Haraguchi et al. 2001, Mansharamani and Wilson 2005, Brachner et al. 2005) is considered to be one of the key steps in the detachment of the nuclear envelope from chromatin (Bengtsson and Wilson 2006, Nichols et al. 2006, Gorjanacz et al. 2007).
In mitotic prophase, chromatin detaches from the nuclear envelope, and this contributes to the nuclear envelope breakdown. VRK1 (and possibly VRK2) mediated phosphorylation of BANF1 (BAF), a protein that simultaneously interacts with DNA, LEM-domain inner nuclear membrane proteins, and lamins (Zheng et al. 2000, Shumaker et al. 2001, Haraguchi et al. 2001, Mansharamani and Wilson 2005, Brachner et al. 2005) is considered to be one of the key steps in the detachment of the nuclear envelope from chromatin (Bengtsson and Wilson 2006, Nichols et al. 2006, Gorjanacz et al. 2007).
所含基因
7 个基因