核膜（NE）再形成的起始
中文名称
通路描述
核膜（NE）的再形成在晚后期/早期末期开始，此时 BANF1（BAF）在中期分散于细胞质中，在共融合的染色体表面积累。这与膜和核内膜蛋白的染色质结合协调进行，包括 EMD（emerin）、TMPO（LAP2beta）、LEM 结构域 3（MAN1）和 LEM 结构域 2（LEM2），以及核丝（Haraguchi et al. 2008，综述由 Wandke 和 Kutay 2013 完成）。BANF1 的 DNA-交叉桥接活性对于单个染色体正确共融合并包裹在单个核中是必需的（Samwer et al. 2017）。
英文描述
Initiation of Nuclear Envelope (NE) Reformation Reassembly of the nuclear envelope (NE) is initiated at late anaphase/early telophase when BANF1 (BAF), which is dispersed throughout the cytoplasm during metaphase, accumulates on the surfaces of coalesced chromosomes. This is coordinated with the chromatin association of membranes and inner nuclear membrane proteins that include EMD (emerin), TMPO (LAP2beta), LEMD3 (MAN1) and LEMD2 (LEM2), and lamins (Haraguchi et al. 2008, reviewed by Wandke and Kutay 2013). The DNA-cross-bridging activity of BANF1 is required for individual chromosomes to properly coalesce for enclosure in a single nucleus (Samwer et al. 2017).
所含基因
18 个基因