胃泌素介导的EGFR转激活
中文名称
通路描述
胃泌素通过下游Gα(q)事件产生的二酰基甘油发挥作用，通过PKC介导的通路转激活EGFR，通过激活MMP3（基质金属蛋白酶3）使前HBEGF（肝素结合表皮生长因子）成熟，从而允许其与EGFR结合，导致EGFR激活（Dufresne et al. 2006, Liebmann 2011）。
英文描述
Scavenging by Class A Receptors Class A scavenger receptors contain an intracellular domain, a transmembrane region, a coiled-coil domain, a collagenous domain, and the SR cysteine-rich domain (reviewed in Areschoug and Gordon 2009, Bowdish and Gordon 2009). The coiled coil domains interact to form trimers. The collagenous domain (Rohrer et al. 1990, Acton et al. 1993) and/or the SR cysteine-rich domain (Brannstrom et al. 2002) bind ligands and determine the specificity of the receptor.
所含基因
18 个基因