SUMO 与 E1 共价连接
中文名称
通路描述
SUMO 与 E1 (UBA2:SAE1) 共价连接。UBA2:SAE1 复合物催化成熟 SUMO 的 C 端甘氨酸与 UBA2 (SAE2) 的半胱氨酸残基 (半胱氨酸 -173) 之间形成硫酯键 (综述于 Wang 和 Dasso 2009, Wilkinson 和 Henley 2010, Hannoun 等 2010, Gareau 和 Lima 2010)。在此过程中，SUMO 的 C 端甘氨酸残基与 ATP 反应生成焦磷酸和瞬态中间体 SUMO 腺苷酸。随后，SUMO 腺苷酸与 UBA2 的半胱氨酸残基的巯基反应 (Olsen 等 2010)。
英文描述
SUMO is conjugated to E1 (UBA2:SAE1) The UBA2:SAE1 complex catalyzes the formation of a thioester linkage between the C-terminal glycine of the mature SUMO and a cysteine residue (cysteine-173) in UBA2 (SAE2) (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun et al. 2010, Gareau and Lima 2010). During the process the C-terminal glycine residue of SUMO is reacted with ATP to yield pyrophosphate and a transient intermediate, SUMO adenylate. The SUMO adenylate then reacts with the thiol group of the cysteine residue of UBA2 (Olsen et al. 2010).
所含基因
11 个基因