SUMO 被蛋白酶解
中文名称
通路描述
SUMO 被蛋白酶解。SUMO1、2 和 3 最初以含有 C 端额外残基的前肽形式表达。(SUMO1 有 4 个残基，SUMO2 有 2 个残基，SUMO3 有 11 个残基。) SENP1、2 和 5 是内肽酶，将前体加工为成熟肽 (综述于 Wang 和 Dasso 2009, Wilkinson 和 Henley 2010, Hannoun 等 2010, Gareau 和 Lima 2010)。SENP1 加工 SUMO1 的效率高于 SUMO2 或 SUMO3。SENP2 和 SENP5 加工 SUMO2 的效率高于 SUMO1 或 SUMO3 (Gong 和 Yeh 2006, Mikolajczyk 等 2007)。SENP1 在细胞质和核内穿梭，主要位于细胞核 (Bailey 和 O'hare 2004, Kim 等 2005)。SENP2 也穿梭 (Itahana 等 2006)，主要位于核孔复合物的核质丝上 (Hang 和 Dasso 2002, Zhang 等 2002)。SENP5 主要位于核仁 (Di Bacco 等 2006, Gong 和 Yeh 2006)。
英文描述
SUMO is proteolytically processed SUMO1, 2, and 3 are initially expressed as propeptides containing extra residues at the C-terminus. (SUMO1 has 4 residues, SUMO2 has 2 residues, and SUMO3 has 11 residues,) SENP1, 2, and 5 are endoproteases that process the precursors to produce the mature peptides (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun et al. 2010, Gareau and Lima 2010). SENP1 processes SUMO1 with greater efficiency than SUMO2 or SUMO3. SENP2 and SENP5 process SUMO2 with greater efficiency than SUMO1 or SUMO3 (Gong and Yeh 2006, Mikolajczyk et al. 2007). SENP1 shuttles between the cytosol and nuceoplasm and is predominantly nuclear (Bailey and O'hare 2004, Kim et al. 2005). SENP2 also shuttles (Itahana et al. 2006) and is mainly located on nucleoplasmic filaments of the nuclear pore complex (Hang and Dasso 2002, Zhang et al. 2002). SENP5 is located mostly in the nucleolus (Di Bacco et al. 2006, Gong and Yeh 2006).
所含基因
6 个基因