转录因子 SUMO 化
中文名称
通路描述
被分类为转录因子的蛋白质构成了 SUMO 化靶标的不成比例的数量。在大多数情况下，SUMO 化抑制转录激活，但在某些情况下，如 TP53（p53）SUMO 化可以增强激活。SUMO 化对转录的抑制可能是由于干扰 DNA 结合、重新定位到不活跃的核小体或招募抑制性辅因子（如组蛋白去乙酰化酶）所致（综述：Girdwood et al. 2004, Gill 2005）。
英文描述
SUMOylation of transcription factors Proteins classified as transcription factors constitute a disproportionate number of SUMOylation targets. In most cases SUMOylation inhibits transcriptional activation, however in some cases such as TP53 (p53) SUMOylation can enhance activation. Inhibition of transcription by SUMOylation may be due to interference with DNA binding, re-localization to inactive nuclear bodies, or recruitment of repressive cofactors such as histone deacetylases (reviewed in Girdwood et al. 2004, Gill 2005).
所含基因
20 个基因