IRF3介导的I型干扰素诱导
中文名称
通路描述
TBK1和干扰素调节因子3(IRF3)是细菌或病毒感染期间诱导I型干扰素的关键调节因子。TBK1被发现与具有不同支架蛋白的复合物结合，似乎将TBK1靶向到不同的亚细胞 compartment[ Hemmi H等 2004; Oganesyan G等 2006; Chariot A等 2002; Huang J等 2005]。STING与TBK1和IRF3结合。一旦STING被刺激，其C末端作为信号支架招募IRF3和TBK1，导致TBK1依赖的IRF3磷酸化。IRF3的磷酸化促进了其二聚化和核转位，在那里它触发干扰素刺激基因(ISGs)的转录(Tanaka Y和Chen ZJ 2012)。
英文描述
IRF3-mediated induction of type I IFN TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3) are central regulators of type-I interferon induction during bacterial or viral infection. TBK1 was found to form complexes with distinct scaffolding proteins that appeared to target TBK1 to different subcellular compartments [Hemmi H et al 2004; Oganesyan G et al 2006; Chariot A et al 2002; Huang J et al 2005]. STING interacted with both TBK1 and IRF3. Once STING is stimulated, its C-terminus served as a signaling scaffold to recruit IRF3 anhd TBK1, which led to TBK1-dependent phosphorylation of IRF3. Phosphorylation of IRF3 promoted its dimerization and translocation to the nucleus, where it triggered the transcription of interferon stimulated genes (ISGs) (Tanaka Y and Chen ZJ 2012).
所含基因
13 个基因