端粒C链上的聚合酶切换
中文名称
通路描述
在G-Rich链上合成引物后，复制因子C结合到起始DNA的3'-末端以触发聚合酶切换。由于Pol alpha催化活性是非过程性的，且复制因子C与引物模板连接处紧密结合，导致Pol alpha:引物酶复合物周转。当Pol alpha-引物酶复合物被从引物上置换后，增殖细胞核抗原(PCNA)结合形成"滑动夹"结构。随后复制因子C解离，DNA聚合酶delta结合并催化过程性DNA合成。
英文描述
TRP channels Transient receptor potential (TRP) channel proteins were first discovered in Drosophila melanogaster and have many homologues in other species including humans. TRPs form cationic channels that can detect sensory stimuli such as temperature, pH or oxidative stress and transduce that into either electrical (change in membrane potential) or chemical signals (change in intracellular Ca2+ concentration). In humans, there are 28 TRP genes arranged into 6 subfamilies; TRPA, TRPC, TRPM, TRPML, TRPP, and TRPV (Wu et al. 2010). Each TRP channel subunit consists of six putative transmembrane-spanning segments (S1-S6) with a pore-forming loop between S5 and S6. These subunits assemble into tetramers to form functional channels. All functionally characterized TRP channels are permeable to Ca2+ except TRMP4 and 5 which are only permeable to monovalent cations such as Na+ (Latorre et al. 2009). Most TRPs can cause channelopathies which are risk factors for many disease states (Nilius & Owsianik 2010).
所含基因
28 个基因