通过鲨烯（lathosterol）途径的鲨烯醇生物合成
中文名称
通路描述
鲨烯醇转化为胆固醇的过程可以通过两条途径进行：其中一种途径是侧链异癸基双键的还原作为最后一步（即鲨烯醇途径，也称为 Bloch 途径），另一种途径是侧链异癸基双键的还原作为第一步（即鲨烯醇途径，也称为 Kandutsch-Russell 途径）。前者在肝脏和其他组织中较为突出，而后者在皮肤中较为突出，其中它可能作为 7-脱氢胆固醇的来源，后者是合成维生素 D 的起始物质。
英文描述
Nuclear Pore Complex (NPC) Disassembly Nuclear envelope breakdown in mitosis involves permeabilization of the nuclear envelope through disassembly of the nuclear pore complex (NPC) (reviewed by Guttinger et al. 2009). Nucleoporin NUP98, located at both the cytoplasmic and the nucleoplasmic side of the NPC (Griffis et al. 2003), and involved in the formation of the transport barrier through its FG (phenylalanine glycine) repeats that protrude into the central cavity of the NPC (Hulsmann et al. 2012), is probably the first nucleoporin that dissociates from the NPC at the start of mitotic NPC disassembly (Dultz et al. 2008). NUP98 dissociation is triggered by phosphorylation. Phosphorylation of NUP98 by CDK1 and NIMA family kinases NEK6 and/or NEK7 is needed for NUP98 dissociation from the NPC (Laurell et al. 2011). While the phosphorylation of NUP98 by CDK1 and NEK6/7 is likely to occur simultaneously, CDK1 and NEK6/7-mediated phosphorylations are shown as separate events, for clarity purposes.
所含基因
33 个基因