c-FLIP 的调节
中文名称
通路描述
c-FLIP 蛋白 (CASP8 和 FADD 样凋亡调节因子或 c-FLICE 抑制蛋白) 是含有死亡执行结构域 (DED) 的蛋白，它们被招募到死亡诱导信号复合物 (DISC) 以调节 caspase-8 的激活。已发现 c-FLIP 的 13 种不同的剪接变体中，有 3 种在蛋白质水平上表达：26 kDa 的短形式 FLIP(S)，24 kDa 的形式 FLIP(R)，以及 55 kDa 的长形式 FLIP(L) (Irmler M et al. 1997; Shu HB et al. 1997; Srinivasula SM et al. 1997; Scaffidi C et al. 1999; Golks A et al. 2005; Haag C et al. 2011)。所有 c-FLIP 蛋白在 N 端都携带两个 DED，可与 FADD 和 procaspase-8 结合。除了两个 DED 外，FLIP(L) 还包含一个大的 (p20) 和一个小的 (p12) caspase 样结构域，但不具有催化活性。FLIP(S) 和 FLIP(R) 由两个 DED 和一个小的 C 端组成。FLIP(L) 的表达水平可能作为抗凋亡或促凋亡因子发挥作用，而 FLIP(S) 和 FLIP(R) 通过阻止 caspase-8 在受体水平上的加工来保护细胞免受凋亡 (Scaffidi C et al. 1999; Golks A et al. 2005; Toivonen HT et al. 2011; Fricker N et al. 2010)。
英文描述
Regulation by c-FLIP c-FLIP proteins (CASP8 and FADD-like apoptosis regulators or c-FLICE inhibitory proteins) are death effector domain (DED)-containing proteins that are recruited to the death-inducing signaling complex (DISC) to regulate activation of caspases-8. Three out of 13 distinct spliced variants of c-FLIP had been found to be expressed at the protein level, the 26 kDa short form FLIP(S), the 24 kDa form FLIP(R), and the 55 kDa long form FLIP(L) (Irmler M et al. 1997; Shu HB et al. 1997; Srinivasula SM et al. 1997; Scaffidi C et al. 1999; Golks A et al. 2005; Haag C et al. 2011)All c-FLIP proteins carry two DEDs at their N termini, which can bind FADD and procaspase-8. In addition to two DEDs, FLIP(L) contains a large (p20) and a small (p12) caspase-like domain without catalytic activity. FLIP(S) and FLIP(R) consist of two DEDs and a small C terminus. Depending on its level of expression FLIP(L) may function as an anti-apoptotic or pro-apoptotic factor, while FLIP(S) and FLIP(R) protect cells from apoptosis by blocking the processing of caspase-8 at the receptor level (Scaffidi C et al. 1999; Golks A et al. 2005; Toivonen HT et al. 2011; Fricker N et al. 2010).
所含基因
11 个基因