Netrin-1 信号
中文名称
通路描述
Netrins 是分泌的蛋白质，在神经系统发育中神经迁移和轴突导向中发挥关键作用。迄今为止，已在小鼠和人类中描述了几种 Netrins：Netrin-1、-3/NTL2、-4/h 和 G-Netrins。Netrin-1 是该家族中最受研究的成员，并通过其与受体 DCC 和 UNC5 的相互作用，在神经系统发育期间发挥关键作用，主要参与神经导航。Deleted in colorectal cancer (DCC) 家族成员（包括脊椎动物中的 DCC 和 Neogenin）介导 Netrin 诱导的轴突吸引，而 C. elegans UNC5 受体及其脊椎动物同源物 Unc5a-Unc5d 介导排斥。
英文描述
Netrin-1 signaling Netrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse and humans: Netrin-1, -3/NTL2, -4/h and G-Netrins. Netrin-1 is the most studied member of the family and has been shown to play a crucial role in neuronal navigation during nervous system development mainly through its interaction with its receptors DCC and UNC5. Members of the Deleted in colorectal cancer (DCC) family- which includes DCC and Neogenin in vertebrates- mediate netrin-induced axon attraction, whereas the C. elegans UNC5 receptor and its four vertebrate homologs Unc5a-Unc5d mediate repulsion.
所含基因
19 个基因