SDK 相互作用
中文名称
通路描述
SDK 相互作用侧伴-1（SDK1）和侧伴-2（SDK2）是免疫球蛋白超家族表达的视网膜神经元非重叠亚群细胞粘附分子。它们已被证明作为神经元靶向分子发挥作用，引导发育中的神经元到达特定突触。SDK 在连接 SDK 表达的前后突触连接处集中，表明其同源粘附特性促进突触的形成或稳定。SDK 促进视网膜层特异性突触连接，并且对于检测运动的神经元回路形成至关重要（Krishnaswamy 等，2015）。
英文描述
SDK interactions Sidekick-1 (SDK1) and sidekick-2 (SDK2) are cell adhesion molecules of the immunoglobulin superfamily expressed by nonoverlapping subsets of retinal neurons. They have been shown to function as neuronal targeting molecules, guiding developing neurons to specific synapses.
SDKs are concentrated at synapses that connect SDK-expressing pre- and postsynaptic partners, suggesting that their homophilic adhesion properties promote formation or stabilization of synapses.
SDKs promotes lamina-specific synaptic connections in the retina and are specifically required for the formation of neuronal circuits that detect motion (Krishnaswamy et al. 2015).
SDKs are concentrated at synapses that connect SDK-expressing pre- and postsynaptic partners, suggesting that their homophilic adhesion properties promote formation or stabilization of synapses.
SDKs promotes lamina-specific synaptic connections in the retina and are specifically required for the formation of neuronal circuits that detect motion (Krishnaswamy et al. 2015).
所含基因
2 个基因