L1CAM 相互作用
中文名称
通路描述
L1CAM 相互作用 L1 家族细胞粘附分子（L1CAMs）是免疫球蛋白超家族跨膜受体的一个亚族，由四个结构相关的蛋白质组成：L1、L1 的同源物（CHL1）、NrCAM 和神经节苷脂。这些 CAM 含有六个 Ig 样结构域、五个或六个纤连蛋白样重复、一个跨膜区域和一个胞质区域。L1CAM 家族已被涉及神经系统发育过程中的一些过程，包括轴突生长、轴突束状化和神经元间粘附。L1CAM 成员主要在发育期间由神经元以及某些非神经元细胞表达。除了 CHL1 外，L1 家族的其他成员都含有一个可剪接的 12 个核苷酸外显子，编码神经突剪接形式中的氨基酸残基 RSLE，但在非神经元细胞中缺失。L1CAM 成员的细胞外区域各不相同，并因其与细胞外异源配体相互作用的能力而不同。L1 配体包括其他 Ig 域 CAM（如 NCAM、TAG-1/轴突蛋白和 F11）、蛋白聚糖分子（神经can）、β1 整合素和细胞外基质蛋白层粘连蛋白、神经丝蛋白-1、FGF 和 EGF 受体。其中一些 L1 相互作用蛋白也与其他 L1CAM 成员结合。例如，TAG-1/轴突蛋白与 L1 和 NrCAM 结合；L1、神经节苷脂和 CHL1 与接触素家族成员结合。L1CAM 成员的胞质区域最保守。尽管如此，它们的胞质结合伙伴不同，甚至具有相似结合伙伴的分子也可能参与不同的信号复合物和机制。L1CAM 最保守的特征是它们与肌动蛋白细胞骨架调节蛋白锚蛋白相互作用的能力。胞质锚蛋白结合域在整个 L1 家族中表现出最高的氨基酸保守度。
英文描述
L1CAM interactions The L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L1 (CHL1), NrCAM, and Neurofascin. These CAMs contain six Ig like domains, five or six fibronectin like repeats, a transmembrane region and a cytoplasmic domain. The L1CAM family has been implicated in processes integral to nervous system development, including neurite outgrowth, neurite fasciculation and inter neuronal adhesion.
L1CAM members are predominately expressed by neuronal, as well as some nonneuronal cells, during development. Except CHL1 all the other members of L1 family contain an alternatively spliced 12-nclueotide exon, encoding the amino acid residues RSLE in the neuronal splice forms but missing in the non-neuronal cells. The extracellular regions of L1CAM members are divergent and differ in their abilities to interact with extracellular, heterophilic ligands. The L1 ligands include other Ig-domain CAMs (such as NCAM, TAG-1/axonin and F11), proteoglycans type molecules (neurocan), beta1 integrins, and extra cellular matrix protein laminin, Neuropilin-1, FGF and EGF receptors. Some of these L1-interacting proteins also bind to other L1CAM members. For example TAG-1/axonin interact with L1 and NrCAM; L1, neurofascin and CHL1 binds to contactin family members. The cytoplasmic domains of L1CAM members are most highly conserved. Nevertheless, they have different cytoplasmic binding partners, and even those with similar binding partners may be involved in different signaling complexes and mechanisms. The most conserved feature of L1CAMs is their ability to interact with the actin cytoskeletal adapter protein ankyrin. The cytoplasmic ankyrin-binding domain, exhibits the highest degree of amino acid conservation throughout the L1 family.
L1CAM members are predominately expressed by neuronal, as well as some nonneuronal cells, during development. Except CHL1 all the other members of L1 family contain an alternatively spliced 12-nclueotide exon, encoding the amino acid residues RSLE in the neuronal splice forms but missing in the non-neuronal cells. The extracellular regions of L1CAM members are divergent and differ in their abilities to interact with extracellular, heterophilic ligands. The L1 ligands include other Ig-domain CAMs (such as NCAM, TAG-1/axonin and F11), proteoglycans type molecules (neurocan), beta1 integrins, and extra cellular matrix protein laminin, Neuropilin-1, FGF and EGF receptors. Some of these L1-interacting proteins also bind to other L1CAM members. For example TAG-1/axonin interact with L1 and NrCAM; L1, neurofascin and CHL1 binds to contactin family members. The cytoplasmic domains of L1CAM members are most highly conserved. Nevertheless, they have different cytoplasmic binding partners, and even those with similar binding partners may be involved in different signaling complexes and mechanisms. The most conserved feature of L1CAMs is their ability to interact with the actin cytoskeletal adapter protein ankyrin. The cytoplasmic ankyrin-binding domain, exhibits the highest degree of amino acid conservation throughout the L1 family.
所含基因
14 个基因