DSCAM 相互作用
中文名称
通路描述
DSCAM（Down syndrome cell adhesion molecule）是 Ig 超家族细胞粘附分子（CAMs）的成员之一，其结构域架构包括 10 个 Ig 结构域、6 个纤连蛋白 III 型（FN）重复、一个跨膜区和一个 C 端胞质结构域。DSCAM 与 Down 综合征（DS）有关，因为 DSCAM 基因位于染色体上，但尚无证据表明 DSCAM 直接参与 DS。它可能作为细胞表面受体介导轴突导向。除了这些重要的影响外，关于哺乳动物系统中 DSCAM 信号转导的生理功能或分子机制知之甚少。人类中存在一个 closely related 的 DSCAM 同源物 Down syndrome cell adhesion moleculelike protein 1（DSCAML1）。这两种蛋白质都参与同型细胞间相互作用。
英文描述
DSCAM interactions DSCAM (Down syndrome cell adhesion molecule) is one of the members of the Ig superfamily CAMs with a domain architecture comprising 10 Ig domains, 6 fibronectin type III (FN) repeats, a single transmembrane and a C terminal cytoplasmic domain. DSCAM is implicated in Down syndrome (DS) due to the chromosomal location of the DSCAM gene, but no evidence supports a direct involvement of DSCAM with DS. It likely functions as a cell surface receptor mediating axon pathfinding. Besides these important implications, little is known about the physiological function or the molecular mechanism of DSCAM signal transduction in mammalian systems. A closely related DSCAM paralogue Down syndrome cell adhesion moleculelike protein 1 (DSCAML1) is present in humans. Both these proteins are involved in homophilic intercellular interactions.
所含基因
4 个基因