快激肽受体结合快激肽
中文名称
通路描述
快激肽是神经肽家族中最大的家族之一，因其能迅速引起肠道组织收缩而得名。快激肽兴奋神经元，引发行为反应，是强效的血管扩张剂和许多平滑肌的收缩剂。快激肽家族具有共同的C端序列Phe-X-Gly-Leu-Met-NH2（其中X可以是芳香族或脂肪族氨基酸），长度在10到12个残基之间。这些肽类通过快激肽受体发挥其作用，人类中有三种类型的快激肽受体（NK1、2和3）。人类中有两个快激肽肽基因，分别为TAC1和TAC3。TAC1编码物质P和物质K，而TAC3编码神经激肽B。这些受体的拮抗剂是抗抑郁剂、抗焦虑药和抗精神病药的有效候选药物。
英文描述
Tachykinin receptors bind tachykinins Tachykinin peptides are one of the largest family of neuropeptides, so named due to their ability to rapidly induce contraction of gut tissue. Tachykinins excite neurons, elicit behavioural responses, are potent vasodilators and contract many smooth muscles. The tachykinin family is characterized by a common C-terminal sequence, Phe-X-Gly-Leu-Met-NH2 (where X can be either an aromatic or an aliphatic amino acid) and are ten to twelve residues long.
These peptides elicit their effects via the tachykinin receptors, of which there are three types in humans (NK1,2 and 3). There are two human tachykinin peptide genes in humans, TAC1 and TAC3. TAC1 encodes substance P and substance K while TAC3 encodes neurokinin B.
Antagonists of these receptors are promising candidates for classes of antidepressants, anxiolytics and antipsychotics.
These peptides elicit their effects via the tachykinin receptors, of which there are three types in humans (NK1,2 and 3). There are two human tachykinin peptide genes in humans, TAC1 and TAC3. TAC1 encodes substance P and substance K while TAC3 encodes neurokinin B.
Antagonists of these receptors are promising candidates for classes of antidepressants, anxiolytics and antipsychotics.
所含基因
5 个基因