ATF6 (ATF6-alpha)
中文名称
通路描述
ATF6-alpha 是一种跨膜蛋白，正常情况下位于内质网膜上。其胞质 C 端结构域与 BiP 结合，屏蔽两个 Golgi 靶向区域，从而将 ATF6-alpha 保留在内质网中。当 BiP 与内质网中的未折叠蛋白相互作用时，ATF6-alpha 解离并转运至高尔基体，在那里被 S1P 和 S2P 蛋白酶切割，释放出 ATF6-alpha 的 N 端结构域进入细胞质。进入细胞核后，N 端结构域作为转录因子激活编码 chaperones 的基因。
英文描述
ATF6 (ATF6-alpha) activates chaperones ATF6-alpha is a transmembrane protein that normally resides in the Endoplasmic Reticulum (ER) membrane. Here its luminal C-terminal domain is associated with BiP, shielding 2 Golgi-targeting regions and thus keeping ATF6-alpha in the ER. Upon interaction of BiP with unfolded proteins in the ER, ATF6-alpha dissociates and transits to the Golgi where it is cleaved by the S1P and S2P proteases that reside in the Golgi, releasing the N-terminal domain of ATF6-alpha into the cytosol. After transiting to the nucleus, the N-terminal domain acts as a transcription factor to activate genes encoding chaperones.
所含基因
4 个基因