CD28共刺激
中文名称
通路描述
CD28信号在塑造免疫反应方面起关键作用，通过确保有效的T细胞激活并增强T细胞生存和增殖。当CD28与其配体结合时，B7 - 1（CD80）和B7 - 2（CD86）上的抗原呈递细胞提供必要的第二信号，补充T细胞受体（TCR）激活。这种共刺激信号导致白细胞介素 - 2（IL - 2）的产生，支持T细胞的克隆扩增，促进其增殖和生存，通过启动抗凋亡途径（Ribot等，2012，Alegre等，2001）。CD28的胞质尾在配体结合后，由Src家族激酶如LCK和FYN磷酸化，触发涉及PI3K、VAV - 1、Tec家族激酶、AKT和其他适配蛋白的下游信号通路（Sharpe & Freeman 2002；Chen & Flies 2013）。
英文描述
Co-stimulation by CD28 CD28 signaling plays a critical role in shaping immune responses by ensuring effective T-cell activation and enhancing T-cell survival and proliferation. When CD28 engages its ligands, B7-1 (CD80) and B7-2 (CD86), on antigen-presenting cells, it provides an essential secondary signal that complements T-cell receptor (TCR) activation. This costimulatory signal leads to the production of interleukin-2 (IL-2), which supports the clonal expansion of T cells, promoting both their proliferation and survival by initiating anti-apoptotic pathways (Ribot et al. 2012, Alegre et al. 2001).
The cytoplasmic tail of CD28, upon ligand binding, undergoes phosphorylation by Src family kinases like LCK and FYN, triggering downstream signaling pathways involving PI3K, VAV-1, Tec family kinases, AKT, and other adaptor proteins (Sharpe & Freeman 2002; Chen & Flies 2013).
The cytoplasmic tail of CD28, upon ligand binding, undergoes phosphorylation by Src family kinases like LCK and FYN, triggering downstream signaling pathways involving PI3K, VAV-1, Tec family kinases, AKT, and other adaptor proteins (Sharpe & Freeman 2002; Chen & Flies 2013).
所含基因
19 个基因