植物酸 α-氧化
中文名称
通路描述
植物酸（植物酸）通过反刍动物代谢叶绿素产生，并作为乳制品的组成部分进入人类饮食（Baxter 1968）。它可以作为 PPAR 和其他核受体激动剂，但其正常的人体生理作用尚不清楚。它通过五步 α-氧化反应序列进行代谢，产生 pristanoyl-CoA，后者是 β-氧化底物。这些反应发生在过氧化物酶体基质中，其失败与 Refsum 病相关（Wanders 等，2003）。
英文描述
Alpha-oxidation of phytanate Phytanic acid arises through ruminant metabolism of chlorophyll and enters the human diet as a constituent of dairy products (Baxter 1968). It can act as an agonist for PPAR and other nuclear hormone receptors, but its normal role in human physiology, if any, is unclear. It is catabolized via a five-step alpha-oxidation reaction sequence that yields pristanoyl-CoA, which is turn is a substrate for beta-oxidation. These reactions take place in the peroxisomal matrix and their failure is associated with Refsum disease (Wanders et al. 2003).
所含基因
5 个基因