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Formation of tubulin folding intermediates by CCT/TriC

Reactome ID: R-HSA-389960

中文名称

CCT/TriC介导的肌动蛋白折叠中间体的形成

通路描述

CCT/TriC 与未折叠的α-或β-肌动蛋白形成二聚体复合物(Frydman et al., 1992; Gao et al., 1993)。由 TriC 产生的肌动蛋白折叠中间体是不稳定的(Gao et al., 1993)。生成正确折叠的α-和β-肌动蛋白以及形成α/β-肌动蛋白异二聚体还需要五个额外的蛋白质辅因子(辅因子 A-E),这些辅因子对于生成正确折叠的α-和β-肌动蛋白以及形成α/β-肌动蛋白异二聚体至关重要(Gao et al., 1993)(Tian et al., 1997, Cowan and Lewis 2001)。
英文描述
Formation of tubulin folding intermediates by CCT/TriC TriC/CCT forms a binary complex with unfolded alpha- or beta-tubulin (Frydman et al., 1992; Gao et al., 1993). The tubulin folding intermediates produced by TriC are unstable (Gao et al., 1993). Five additional protein cofactors (cofactor A-E) are required for the generation of properly folded alpha- and beta-tubulin and for the formation of alpha/beta-tubulin heterodimers (Gao et al., 1993) (Tian et al., 1997, Cowan and Lewis 2001).

所含基因

9 个基因