毒蕈碱型乙酰胆碱受体
中文名称
通路描述
毒蕈碱型乙酰胆碱受体（mAChRs）受体之所以得名，是因为它们对毒蕈碱比尼古丁更敏感（Ishii M and Kurachi Y, 2006）。它们的对应物是烟碱型乙酰胆碱受体（nAChRs），也是自主神经系统中重要的离子通道受体。许多药物可以通过作为选择性激动剂或拮抗剂来操纵这两种截然不同的受体。mAChRs 结合生物胺乙酰胆碱，具有广泛的组织分布，并参与控制许多中枢和周围生理反应，特别是 voluntary 肌肉收缩。它们也是人类疾病如阿尔茨海默病、帕金森病和精神分裂症的主要药物靶点。这个 G 蛋白偶联受体家族包含五个成员，分别标记为 M1-M5，并根据它们与 G 蛋白的主要耦合方式分为两组：M2 和 M4 受体耦合到 Gi/o 蛋白，而 M1、M3 和 M5 受体耦合到 Gq/11 蛋白（Caulfield MP and Birdsall NJ, 1998）。
英文描述
Muscarinic acetylcholine receptors Muscarinic acetylcholine (mAChRs) receptors were so named because they are more sensitive to muscarine than to nicotine (Ishii M and Kurachi Y, 2006). Their counterparts are nicotinic acetylcholine receptors (nAChRs), ion channels receptors that are also important in the autonomic nervous system. Many drugs can manipulate these two distinct receptors by acting as selective agonists or antagonists. mAChRs bind to the bioamine acetylcholine, have a widespread tissue distribution and are involved in the control of numerous central and peripheral physiological responses, particularly voluntary muscle contraction. They are also major targets for drugs in human diseases such as Alzheimer's, Parkinson's and schizophrenia. This family of G-protein coupled receptors consists of five members designated M1-M5 and are sub-divided into two groups based on their primary coupling to G proteins. M2 and M4 receptors couple to Gi/o proteins and M1, M3 and M5 receptors couple to Gq/11 proteins (Caulfield MP and Birdsall NJ, 1998).
所含基因
5 个基因