信号调节蛋白家族相互作用
中文名称
通路描述
信号调节蛋白α（SIRPA, SHPS1, CD172a）是一种主要表达于髓系细胞上的跨膜蛋白。CD47 是一种广泛表达的跨膜蛋白，是 SIRPα的配体，这两个蛋白共同构成细胞间通信系统。SIRPA 与 CD47 的结合对于调节迁移和吞噬作用很重要。SIRPA 作为 docking 蛋白，在应对细胞外刺激时招募并激活膜上的 PTPN6（SHP-1）或 PTPN11（SHP-2）。SIRPA 还与其他细胞内蛋白结合，包括 Src 激酶相关蛋白（SKAP2 SKAP55hom/R）、Fyn 结合蛋白/SLP-76 相关磷酸蛋白（FYB/SLAP-130）和酪氨酸激酶 PYK2。SIRPA 还结合细胞外蛋白，包括表面活性蛋白 A（SP-A）和表面活性蛋白 D（SP-D）。
SIRP 家族成员 SIRPB 和 SIRPG 具有高序列相似性和相似的细胞外结构拓扑，包括三个 Ig 结构域，但它们的配体结合拓扑可能不同。SIRPB 在髓系细胞上表达，包括单核细胞、粒细胞和树突状细胞。已知没有天然配体。SIRPG 可以结合 CD47，但亲和力低于 SIRPA。
SIRP 家族成员 SIRPB 和 SIRPG 具有高序列相似性和相似的细胞外结构拓扑，包括三个 Ig 结构域，但它们的配体结合拓扑可能不同。SIRPB 在髓系细胞上表达，包括单核细胞、粒细胞和树突状细胞。已知没有天然配体。SIRPG 可以结合 CD47，但亲和力低于 SIRPA。
英文描述
Signal regulatory protein family interactions Signal regulatory protein alpha (SIRPA, SHPS1, CD172a) is a transmembrane protein expressed mostly on myeloid cells. CD47, a widely expressed transmembrane protein, is a ligand for SIRP alpha, with the two proteins constituting a cell-cell communication system. The interaction of SIRPA with CD47 is important for the regulation of migration and phagocytosis. SIRPA functions as a docking protein to recruit and activate PTPN6 (SHP-1) or PTPN11 (SHP-2) at the cell membrane in response to extracellular stimuli. SIRPA also binds other intracellular proteins including the adaptor molecules Src kinase-associated protein (SKAP2 SKAP55hom/R), Fyn-binding protein/SLP-76-associated phosphoprotein (FYB/SLAP-130) and the tyrosine kinase PYK2. SIRPA also binds the extracellular proteins, surfactant-A (SP-A) and surfactant-D (SP-D).
The SIRP family members SIRPB and SIRPG show high sequence similarity and similar extracellular structural topology, including three Ig domains, but their ligand binding topology might differ. SIRPB is expressed on myeloid cells, including monocytes, granulocytes and DCs. It has no known natural ligand. SIRPG can bind CD47 but with lower affinity than SIRPA.
The SIRP family members SIRPB and SIRPG show high sequence similarity and similar extracellular structural topology, including three Ig domains, but their ligand binding topology might differ. SIRPB is expressed on myeloid cells, including monocytes, granulocytes and DCs. It has no known natural ligand. SIRPG can bind CD47 but with lower affinity than SIRPA.
所含基因
15 个基因