通过α2肾上腺素能受体介导的肾上腺素信号
中文名称
通路描述
肾上腺素（肾上腺素）通过α2肾上腺素能受体介导的信号具有多种效应，包括胰腺中胰岛素释放的抑制、胰腺中胰高血糖素的诱导、胃肠道括约肌的收缩、神经元突触中的负反馈过程以及血小板聚集的促进。该受体优先与Gi类异三聚体G蛋白结合，导致腺苷酸环化酶抑制，从而降低cAMP水平。
英文描述
Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline (epinephrine) signalling via the alpha-2 adrenergic receptor has many effects including inhibition of insulin release in pancreas, induction of glucagon release from pancreas, contraction of sphincters of the gastrointestinal tract, negative feedback processes in neuronal synapses and stimulation of platelet aggregation. This receptor preferentially couples to members of the Gi class of heterotrimeric G-proteins, leading to inhibition af adenylate cyclase and thereby decreased cAMP levels.
所含基因
3 个基因