通过P2Y纯受体12介导的ADP信号
中文名称
通路描述
P2Y1和P2Y12的协同激活对于血小板完全激活是必要的。P2Y1与Gq结合，有助于从内部储存中释放钙，导致弱且可逆的血小板聚集。P2Y12与Gi结合，抑制腺苷酸环化酶，导致cAMP降低，进而降低cAMP依赖性蛋白激酶活性，增加细胞内[Ca2+]，这对于激活是必需的（Woulfe等人，2001）。在激活的血小板中，P2Y12信号对于由胶原、凝血酶、血栓素、肾上腺素和血清素等所有血小板激动剂引起的聚集放大是必需的。P2Y12激活导致血栓素生成和分泌的增强，导致不可逆的血小板聚集和血栓稳定。
英文描述
ADP signalling through P2Y purinoceptor 12 Co-activation of P2Y1 and P2Y12 is necessary for complete platelet activation. P2Y1 is coupled to Gq and helps trigger the release of calcium from internal stores, leading to weak and reversible platelet aggregation. P2Y12 is Gi coupled, inhibiting adenylate cyclase, leading to decreased cAMP, a consequent decrease in cAMP-dependent protein kinase activity which increases cytoplasmic [Ca2+], necessary for activation (Woulfe et al. 2001).
In activated platelets, P2Y12 signaling is required for the amplification of aggregation induced by all platelet agonists including collagen, thrombin, thromboxane, adrenaline and serotonin. P2Y12 activation causes potentiation of thromboxane generation, secretion leading to irreversible platelet aggregation and thrombus stabilization.
In activated platelets, P2Y12 signaling is required for the amplification of aggregation induced by all platelet agonists including collagen, thrombin, thromboxane, adrenaline and serotonin. P2Y12 activation causes potentiation of thromboxane generation, secretion leading to irreversible platelet aggregation and thrombus stabilization.
所含基因
22 个基因