通过PI3Kγ介导的Gβγ信号
中文名称
通路描述
PI3Kγ（PI3KG）是一种异二聚体，由与调节亚基p101或p84结合的催化亚基p110组成。PI3KG在粒细胞中表达最高，其中p101形式占主导地位（约95%）。Gβγ招募PI3KG至细胞膜，既激活PI3KG并提供其底物PIP2的访问，PIP2被转化为PIP3。
英文描述
G beta:gamma signalling through PI3Kgamma PI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predominates (approximately 95%). G beta:gamma recruits PI3KG to the plasma membrane, both activating PI3KG and providing access to its substrate PIP2, which is converted to PIP3.
所含基因
25 个基因