Ras信号
中文名称
通路描述
Ras（Ras-邻近-1）是Ras超家族中的一种小G蛋白。像所有G蛋白一样，Ras在GDP与GTP交换时激活。Ras通过共价连接到其羧基末端的脂质基团靶向至脂质膜。在多种细胞类型中，包括Jurkat T细胞和巨核细胞，Ras在激活后从内体膜移动到细胞膜的现象已被报道。在激活后，Ras发生构象变化，促进多种效应体的招募，触发其参与整合素信号、ERK激活等。
英文描述
Rap1 signalling Rap1 (Ras-proximate-1) is a small G protein in the Ras superfamily. Like all G proteins, Rap1 is activated when bound GDP is exchanged for GTP. Rap1 is targeted to lipid membranes by the covalent attachment of lipid moieties to its carboxyl terminus. Movement of Rap1 from endosomal membranes to the plasma membrane upon activation has been reported in several cell types including Jurkat T cells and megakaryocytes. On activation, Rap1 undergoes conformational changes that facilitate recruitment of a variety of effectors, triggering it's participation in integrin signaling, ERK activation, and others.
所含基因
15 个基因